OpenMS is a C++ library for LC-MS data management and analyses.
It offers an infrastructure for the rapid development of mass spectrometry
related software. OpenMS is free software available under the three clause BSD
license and runs under Windows, MacOSX and Linux.
It comes with a vast variety of pre-built and ready-to-use tools for proteomics
and metabolomics data analysis (TOPPTools) and
powerful 2D and 3D visualization(TOPPView).
OpenMS offers analyses for various quantitation protocols,
including label-free quantitation, SILAC, iTRAQ, SRM, SWATH, etc.
It provides built-in algorithms for de-novo identification and database search,
as well as adapters to other state-of-the art tools like XTandem, Mascot,
OMSSA, etc.
It supports easy integration of OpenMS built tools into workflow engines like
Knime, Galaxy, WS-Pgrade, and TOPPAS via the TOPPtools concept and
a unified parameter handling via a 'common tool description' (CTD) scheme.
The OpenMS Proteomics Pipeline is a pipeline for
the analysis of HPLC-MS data.
It consists of several small applications that
can be chained to create analysis pipelines tailored
for a specific problem.
The TOPP tools are divided into several subgroups:
- Graphical Tools
- File Handling
- Signal Processing and Preprocessing
- Quantitation
- Map Alignment
- Protein/Peptide Identification
- Protein/Peptide Processing
- Targeted Experiments
- Peptide Property Prediction
- Misc
